中国药理学通报2016，Vol.32Issue(6)：806-811,6.DOI:10.3969/j.issn.1001-1978.2016.06.014
多肽HM-3对人非小细胞肺癌裸鼠移植瘤抑制作用研究
Antitumor effects of peptide HM-3 against non-small cell lung cancer xenografts in nude mice
摘要
Abstract
Aims Toevaluatethepharmacodynamic efficacy of different types of antiangiogenic agents as HM-3 on a non-small cell lung cancer xenografts tumor model .To explore the interaction between the antian-giogenic agents and the tumor microenvironment,and to offer suggestions for clinical therapy.Methods Thenon-smallcelllungcarcinomaxenograftmodelwas established in Balb/c nude mice.The model mice were treated with Docetaxel(10 mg·kg-1 )as the positive control.The mice were parallelly treated with,HM-3 at the doses of 3 mg · kg-1 and 48 mg · kg-1 and, Avastin(5 mg·kg-1 ).The parameters include tumor volume,tumor weight and immunohistochemical analy-sis.Result Animalexperimentsshowedthatdocetaxel had good anti-tumor activity.Tumor growth inhibition by tumor weight of G2 docetaxel(10 mg·kg-1 )group was 60. 80%.Tumor growth inhibition by tumor weight of G3 HM-3(3 mg·kg-1 )group,G4 HM-3(48 mg· kg-1 )group ,G4 Avastin(5 mg·kg-1 )group,were 43. 60%,-34. 80%,44. 40%,respectively.Con-clusion Theantigiogeniceffectisaffectedbytumor growth stage,tumor microenvironment and their work-ing mechanisms.Angiogenesis inhibitors HM-3 has a certain effect of inhibiting tumor growth,but to little a-vail.HM-3 shows on inhibitory effect in a dose-de-pendent manner at the doses of 0~6 mg·kg-1 .HM-3 at a high dose of 48 mg · kg-1 has no inhibitory but promoting effects on human non-small cell lung carci-noma A549 xenografts in nude mice .Special dose-effect relationship indicates that dosage should be paid attention to in the clinical use of blood vessel inhibi-tors.关键词
多肽HM-3/非小细胞性肺癌/贝伐单抗/血管生成抑制剂/裸鼠移植瘤模型/肿瘤微环境/多西他赛Key words
peptide HM-3/non-small cell lung canc-er/Avastin/angiogenesis inhibitor/xenografts in nude mice/tumor microenvironment/docetaxel分类
医药卫生引用本文复制引用
程昊冉,王佳艺,吴小东,郝静超,罗燕平,刘晨,胡加亮,徐寒梅..多肽HM-3对人非小细胞肺癌裸鼠移植瘤抑制作用研究[J].中国药理学通报,2016,32(6):806-811,6.基金项目
国家高技术研究发展计划（863计划）资助项目 （）
