中国药理学通报2016，Vol.32Issue(6)：812-817,6.DOI:10.3969/j.issn.1001-1978.2016.06.015
新药T－006对东莨菪碱所致记忆障碍模型动物学习记忆的改善作用
Effects of new drug T-006 on improving learning and memory abilities in scopolamine-induced dementia Kunming mice
摘要
Abstract
Aim ToexploretheeffectsofnewdrugT-006 on improving learning and memory abilities in scopolamine-induced dementia mice and its possible mechanism.Methods 72maleKunmingmicewere randomly divided into six groups:normal control group,model group,donepezil treatment group,T -006 treatment group with different doses(1,3 and 10 mg·kg-1 ).All mice were treated by intragastric ad-ministration for 14 consecutive days. Learning and memory abilities were tested by a five-day Morris water maze trial from the 1 1 th day.the first 4 days of the five-day Morris water maze,the navigation test was performed,the last day of Morris water maze is the spatial probe test.During the navigation test, mice were intraperitoneally given 2 mg · kg-1 scopolamine 20 minutes before entering the water,while normal control group mice administrated with sterile saline in-stead.Mice were not given T-006 nor scopolamine in spatial probe test.After Morris water maze,all mice were sacrificed for hippocampus and cortex.The activi-ties of AchE and SOD and the levels of GSH and MDA in hippocampus and cortex were measured after tissue harvesting.Results Comparedwithmodelgroup,T-006 could obviously improve learning and memory abil-ities in scopolamine-induced mice, significantly in-crease the levels of SOD and GSH and decrease the levelsofMDAandAchE.Conclusion T-006can significantly improve cognitive abilities in scopolamine-induced dementia mice,and its relevant mechanism may be closely related to its antioxidative effect and the ability to decrease AchE level.关键词
T-006/东莨菪碱/Morris水迷宫/昆明小鼠/海马/皮层/学习记忆能力Key words
T-006/scopolamine/Morris water maze/Kunming mice/hippocampus/cortex/learning and memory abilities分类
医药卫生引用本文复制引用
宋奇,王琴,吴韦黎,邵敏,张宇,张在军,王玉强,陶亮..新药T－006对东莨菪碱所致记忆障碍模型动物学习记忆的改善作用[J].中国药理学通报,2016,32(6):812-817,6.基金项目
国家自然科学基金项目（No 81373439）；广东省科技计划项目（No 2014A020209032）；广州市科技局科技攻关引导项目 （）
