中国药理学通报2016，Vol.32Issue(6)：841-845,5.DOI:10.3969/j.issn.1001-1978.2016.06.020
利福平对小鼠的肝毒性及胆酸代谢基因的影响
Effects of rifampicin on hepatotoxicity and genes related to bile acid metabolism in mice
摘要
Abstract
Aim Toexamineliverdamagebyrifampi-cin and hepatic gene expression related to bile acid me-tabolisminmice.Methods Adultmalemicewere given rifampicin(180 mg·kg-1 ,po)daily for 30 days and(90 mg·kg-1 ,po)daily for 90 days,blood bio-chemistry,histopathology,and gene expression were examined.Results Rifampicinincreasedanimalliver index and serum enzyme activities. Histopathology showed steatosis and spotted feathery-like degenera-tion.Rifampicin increased the expression of CYP7A1 after 30 and 90 days of administration,along with in-creased FXR and SHP.Rifampicin reduced the expres-sion of BSEP after 30 days of high dose administration. Conclusion Repeatedadministrationofrifampicin may cause liver injury and intrahepatic cholestasis in mice,and these effects are associated with the altera-tion of gene expression related to bile acid metabolism.关键词
利福平/肝毒性/胆酸代谢/胆汁淤积/CYP7A1/BSEPKey words
rifampicin/hepatotoxicity/bile acid me-tabolism/cholestasis/CYP7A1/BSEP分类
生物科学引用本文复制引用
徐永吉,李文楷,刘杰,陆远富..利福平对小鼠的肝毒性及胆酸代谢基因的影响[J].中国药理学通报,2016,32(6):841-845,5.基金项目
国家自然科学基金资助项目 （）
