中国药理学通报2016，Vol.32Issue(6)：853-857,5.DOI:10.3969/j.issn.1001-1978.2016.06.022
基于 NMR的免疫抑制小鼠模型血清代谢组学研究
Metabolic analysis of immune suppression mice based on NMR
摘要
Abstract
Aim Toanalyzethecharacteristicsofser-um metabolites in immune suppression mice by using 1HNMR-basedmetabonomics.Methods Twentymale Kunming(KM)mice were randomly divided into two groups:normal group and cyclophosphamide (Cy ) model group.Cy model group was given Cy to induce immune suppression.NMR technology was used to find out the variability of serum metabolites by the method ofOPLS-DA.Results Comparedwithnormalgroup, Cy model group showed a significant decrease in the serum levels of glutamine,glycolprotein,unsaturated lipid,VLDL,LDL,acetone and showed a significant increase in the serum levels of leucine,alanine,tyro-sine, histidine, lactate, glycine, creatine, me-theionine,valine,β-hydrocxy butyrate and carnitine. Conclusions Immunesuppressionmiceareimbal-anced in metabolic network.These findings indicate that lipid metabolism-related metabolites are de-creased,however,β-oxidation of fatty acid,proteoly-sis and glycolysis level are increased.关键词
环磷酰胺/免疫抑制/特异性代谢物/代谢组学/小鼠/氢谱核磁共振Key words
cyclophosphamide/immune suppression/characteristic metabolites/metabonomics/mice/1 H-nuclear magnetic resonance分类
医药卫生引用本文复制引用
斯皮热古丽·阿布都卡地,阿里木·帕塔尔,古孜力克孜·阿布都克热木..基于 NMR的免疫抑制小鼠模型血清代谢组学研究[J].中国药理学通报,2016,32(6):853-857,5.基金项目
国家自然科学基金资助项目 （）
