中国药理学通报2016，Vol.32Issue(6)：885-888,4.DOI:10.3969/j.issn.1001-1978.2016.06.028
组织自发荧光在大鼠心肌缺血实验中的应用
Application of tissue spontaneous fluorescence in myocardial ischemia injury of rats
摘要
Abstract
Aim Todiscusstheapplicationoftissue spontaneous fluorescence in myocardial ischemia injury of rats based on specific fluorescence detection technol-ogy.Methods Thechangeofspontaneousfluores-cence was compared between the myocardial tissue of normal rats and those of rats with myocardial ischemia injury and an quantitative analysis was then made.Re-sult Theresultsshowedthatspontaneousfluorescence of myocardial tissue for myocardial ischemia injury changed significantly.Spontaneous fluorescence signal of injury considerably was enhanced.The fluorescence signal which was quantified by FX Pro had statistical significance compared with normal myocardial tissue,P<0.01orP<0.05.Conclusion Ourresearchshows that spontaneous fluorescence of myocardial tissue can be enhanced obviously after myocardial ischemia inju-ry.Our research provides a method for the research and evaluation of myocardial ischemia injury model in rats which can be used in positioning,qualitative and quan-titative comparative study and in pathological,physio-logical,pharmacological and mechanism study.关键词
大鼠/心肌组织/心肌缺血损伤/N-BT/自发荧光/活体成像系统/定量分析Key words
rat/myocardial tissue/myocardial ischemia injury/N-BT/autofluorescence/in vivo imaging system/quantitative analysis分类
医药卫生引用本文复制引用
李峰杰,张金艳,何萍,李贻奎,赵乐,郝伟,李连达..组织自发荧光在大鼠心肌缺血实验中的应用[J].中国药理学通报,2016,32(6):885-888,4.基金项目
北京自然科学基金面上项目 （）
