中国药业2016，Vol.25Issue(8)：20-22,23,4.
布洛芬－伪麻黄碱衍生物的合成
Synthesis of Ibuprofen-Pseudoephedrine Derivatives
孙丹 1吕敏 2吕振 2李泉 2易八贤3
作者信息
- 1. 黑龙江中医药大学，黑龙江 哈尔滨 150040
- 2. 哈尔滨三联药业股份有限公司，黑龙江 哈尔滨 150025
- 3. 中国医药工业研究总院，上海 201403
- 折叠
摘要
Abstract
Objective To synthesize and prepare the high-purity derivatives of ibuprofen-pseudoephedrine and demonstrate their struc-ture depending on physicochemical properties and spectral characteristics. Methods Ibuprofen and pseudoephedrine were used as the starting material,with EDC as condensing agent in esterification and amidation. The finished products were purified by silica gel column chromatography and recrystallization and the structure of the products was detected. Results The purity of each product was more than 99. 5%,and their spectral characteristics were consistent with the target compound. Conclusion The synthetic method works easily and the finished products are highly pure. Products can be used as impurity reference for the quality control of compound preparation of ibuprofen-pseudoephedrine.关键词
布洛芬/伪麻黄碱/酯化/酰胺化/杂质对照品Key words
ibuprofen/pseudoephedrine/esterification/amidation/impurity reference分类
医药卫生引用本文复制引用
孙丹,吕敏,吕振,李泉,易八贤..布洛芬－伪麻黄碱衍生物的合成[J].中国药业,2016,25(8):20-22,23,4.
