中国药业2016，Vol.25Issue(8)：23-25,26,4.
依折麦布联合氟伐他汀对冠心病高危患者的强化调脂作用
Ezetimibe Combined with Fluvastatin on Intensive Lipid-Lowering in High Risk Patients with Coronary Heart Disease
白延平 1刘智娜 1赵莉 1陈俊民 1高智耀 1王晨霞1
作者信息
- 1. 延安大学附属医院，陕西 延安 716000
- 折叠
摘要
Abstract
Objective To observe Ezetimibe combined fluvastatintin intensive lipid in patients with coronary heart disease risk. Methods 74 cases of patients with high risk of coronary heart disease were randomly divided into observation group and control group,37 cases in each group. The two groups were given the basis of foundation treatment,the control group was added with 2 times dosage of fluvas-tatin(40 mg/d),and the treatment group was added with fluvastatin(20 mg/d)and ezetimibe(10 mg/d). The two groups were treat-ment for 3 months. The clinical efficacy of the two groups were compared,the hs-CRP concentration in blood,total cholesterol (TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C)and low density lipoprotein cholesterol(LDL-C)levels were detect-ed,the Crouse score of carotid plaques was caculated,and the adverse reactions related to the drug were recorded. Results After treat-ment,the total effective rate of the observation group was 75. 68%,which had no statistically significant difference with 67. 57% of the control group( P > 0. 05);the levels of TC,LDL-C and hs-CRP levels decreased in the two groups( P < 0. 05),HDL-C expres-sion levels increased( P < 0. 05),and the range of improvement in the observation groups was better than the control group( P < 0. 05);the Crouse scores of the two groups showed statistically significant difference compared with before treatment,and the decrease in the observation groups was more than the control group( P < 0. 05);the occurrence rate of adverse reaction in the observation group was 10. 81%,which was obviously lower than 21. 62% of the control group( P < 0. 05). Conclusion Ezetimibe combined with fluvastat-intins can adjust blood lipid metabolism in patients with coronary heart disease,can slow hardening of the arteries process to a certain extent,at the same time has no serious adverse reaction,is safer and worthy of clinical promotion.关键词
依折麦布/氟伐他汀/冠心病/高危患者/强化调脂/动脉硬化Key words
ezetimibe/fluvastatintin/coronary heart disease/high risk patient/strengthen lipid/hardening of the arteries分类
医药卫生引用本文复制引用
白延平,刘智娜,赵莉,陈俊民,高智耀,王晨霞..依折麦布联合氟伐他汀对冠心病高危患者的强化调脂作用[J].中国药业,2016,25(8):23-25,26,4.
