中国药业2016，Vol.25Issue(8)：43-44,45,3.
罗库溴铵用于良恶性头颈部肿瘤患者的肌肉松驰效应研究
Muscle Relaxant Effect of Rocuronium Bromide in Patients with Benign and Malignant Head and Neck Tumor
公丕英1
作者信息
- 1. 辽宁省铁岭市中心医院，辽宁 铁岭 112000
- 折叠
摘要
Abstract
Objective To observe the efficacy of rocuronium in muscle relaxants time between different types of tumor patients. Methods 68 patients under general anesthesia in head and neck tumor resection were divided into two groups,Malignant(group A) and Benign (group B),34 case in each group. The two groups received intravenous injection of propofol,fentanyl,rocuronium for anesthesia induc-tion. In clusters stimulate was used to monitor neuromuscular blockade depth,and when the first twitch in the fourth clusters stimulate response (T1) reached the lowest point the endotracheal intubation was conducted. When the T1 recovered to 10% started infusion of rocuronium and maintained at 5% to 10%. After surgery,stopped the use of rocuronium,and used neostigmine for the antagonistic mus-cle relaxant effect. The muscle relaxation index of rocuronium was recorded. Results Compared with group A,the onset time of group B was significantly shorter,the duration of the maximum effect was more extended,the time of T1 recovery to 10%,from 10% to 50%, and the recovery index were significantly shortened( P < 0. 05 );the intubating conditions of group B was better than group A ( P < 0. 05);there was no statistically significant difference between the two groups in the occurrence rate of adverse reactions( P > 0. 05). Conclusion Rocuronium has more sensitive muscle relaxant effect on patients with head and neck benign tumor,the onset time and recovery time in patients with head and neck benign tumor are significantly shortened compared with patients with malignant tumor.关键词
罗库溴铵/头颈部肿瘤/肌松时间Key words
rocuronium/head and neck tumor/muscle relaxants time分类
医药卫生引用本文复制引用
公丕英..罗库溴铵用于良恶性头颈部肿瘤患者的肌肉松驰效应研究[J].中国药业,2016,25(8):43-44,45,3.
