摘要
Abstract
Objective To investigate the related risk factors of adverse reactions in treating osteoporosis with zoledronic acid. Methods 115 patients with osteoporosis in the hospital from September 2014 to November 2015 were selected as the research subjects. All pa-tients were given the treatment of zoledronic acid infusion,and were divided into APR group (76 cases) and non-APR group (39 cases) according to whether the patients had adverse reactions of zoledronic acid or not. The serum calcium level,osteoporosis status condition,creatinine clearance rate,applications of calcium and bone absorption inhibitors,as well as body temperature,pain,gastrointesti-nal tract adverse reaction symptoms,their degree and remission status were observed in the two groups. Results After treatment,the in-cidence rate of adverse reactions was 66. 09%. The rate of gastrointestinal was 1. 74%,the rate of pain in joint,muscle and so on was 47. 83%,and the fever incidence rate was 58. 26%. The single factor analysis showed the adverse reactions had no correlation with age and gender,but it had close correlation whether combination with fractures or not,serum calcium level,whether applications of calcium and bone absorption inhibitor or not,osteocalcin and bone mineral density(T value)levels( P < 0. 05). Multivariate factors logistic re-gression analysis showed applications of calcium and bone absorption inhibitors were protective factors for adverse reactions,and combi-nation with fractures was a high risk factor( P < 0. 05). Conclusion In the treatment of osteoporosis with zoledronic acid,the rate of adverse reactions is higher. The combination with fractures is a high risk factor,and bone absorption inhibitors and calcium are protec-tive factors.关键词
唑来膦酸/骨质疏松症/药品不良反应/危险因素/回归分析Key words
zoledronic acid/osteoporosis/adverse drug reactions/risk factors/regression analysis分类
医药卫生
