中国药业2016，Vol.25Issue(10)：60-62,63,4.
吉西他滨联合卡铂治疗浸润性膀胱癌手术患者临床研究
Clinical Research of Gemcitabine Combined with Carboplatin in Treating Patients with Invasive Bladder Cancer Surgery
刘春林 1渠渊 1张进生 1柴军 1刘宁 1吴宗山1
作者信息
- 1. 首都医科大学附属复兴医院，北京 100038
- 折叠
摘要
Abstract
Objective To observe the clinical efficacy of gemcitabine and carboplatin used in the chemotherapy before the invasive bladder cancer surgery. Methods 100 patients with invasive bladder cancer patients who met the inclusion criteria were randomly divided into the study group and the control group,50 cases in each group. The study group received gemcitabine+carboplatin,the control group re-ceived gemcitabine+cisplatin,21 d was 1 course of treatment. The recent adverse reactions were evaluated in the two groups after com-pleting 2-3 cycles of chemotherapy;after chemotherapy,all patients were treated with surgery that retained the bladder,and the long-term prognosis were observed and compared between the two groups. Results The response rate of the study group was 79. 59%,the total effective rate was 95. 92%,which had no statistically significant difference with 68. 75%,91. 67% of the control group( P > 0. 05);the tumor sizes of the two groups after chemotherapy were significantly reduced compared with before chemotherapy ( P < 0. 05);the gastrointestinal reactions,liver damage,kidney damage,skin rashes and vasculitis of the study group were significantly lower than those of the control group( P < 0. 05);the 1,2,3-year survival rates of the study group were 71. 43%,48. 98%,34. 69%,which were higher than 68. 75%,41. 67%,25. 00% of the control group but without statistically significant difference ( P > 0. 05);the 3-year median survival time of the study group was 24. 5 months,which was longer than 23. 7 months of the control group but without statistically significant difference(χ2= 0. 846,P > 0. 05). Conclusion Preoperative gemcitabine combined with carboplatin in chemotherapy before invasive bladder cancer surgery has equivalent effect with gemcitabine combined with cisplatin,but the former combination has fewer in-cidence of adverse reactions,especially lower incidence of renal damage.关键词
吉西他滨/卡铂/浸润性膀胱癌/化学治疗/临床疗效Key words
gemcitabine/carboplatin/invasive bladder cancer/chemotherapy/clinical efficacy分类
医药卫生引用本文复制引用
刘春林,渠渊,张进生,柴军,刘宁,吴宗山..吉西他滨联合卡铂治疗浸润性膀胱癌手术患者临床研究[J].中国药业,2016,25(10):60-62,63,4.
