中国药业2016，Vol.25Issue(10)：66-68,3.
吲哚美辛肠溶片近红外快速定量方法的建立
Construction of a Quantitative Model for Determination of Indometacin Enteric-Coated Tablets
吴群1
作者信息
- 1. 重庆市食品药品检验检测研究院，重庆 401121; 重庆市药物过程与质量控制工程技术研究中心，重庆 401121
- 折叠
摘要
Abstract
Objective To quantitatively analyze the Indometacin Enteric-coated Tablets by near infrared diffuse reflection spectroscopy technology and chemometrics. Methods 156 batches of Indometacin Enteric-coated Tablets from 8 different manufacturers were chosen for analyzing. The near infrared diffuse reflection spectrum of the samples was collected;the active pharmaceutical ingredient(API)con-tents were determined by the conventional method;the model with the partial least square(PLS) algorithm available in the quant was developed. Results The model was based on cross validation with API from 24. 61% to 32. 96%. 78 batches were used as validation set,the RMSEP was 0. 508%,and the average relative deviation for the validation set was 0. 45%. Conclusion The method is accu-rate,quick and convenient,which can be used for quick analysis in drug control.关键词
吲哚美辛/近红外漫反射光谱/定量模型Key words
indometacin/near infrared spectroscopy/quantitative model分类
医药卫生引用本文复制引用
吴群..吲哚美辛肠溶片近红外快速定量方法的建立[J].中国药业,2016,25(10):66-68,3.
