摘要
Abstract
Objective To assess the clinical effects of reduced glutathione combined with erythropoietin in treatment of anemia in patients with uremia. Methods Seventy two patients were randomly divided into study group and control group with 36 cases in each group. Patients in both groups underwent hemodialysis 3/wk, received conventional medication (oral iron, folic acid, methylcobalamin) and recombinant human erythropoietin injection (EPO) 100~ 150U/kg/wk. If Hb reached 130g/L, EPO dose was reduced by 25%. Patients in study group were given additional reduced glutathione 1.2g, ivgtt, 3/wk. The duration of treatment was 8 weeks in both groups. The RBC, Hb, HCT, SF, SOD, MDA, GSHPx, CRP, TSF, BMI, WHR, Ca2+, K+, Na+were measured before and after treatment. The adverse reactions were observed. Results The overal efficacy rate in study group was high than control group (88.9%, 72.2%, P<0.05). The Hb, RBC, HCT and SOD, GSHPx levels in study group were increased more markedly, than those in control group(P<0.05);while the level of MDA decreased significantly(P<0.05). There were no severe adverse reactions in two groups. Conclusion Reduced glutathione combined with erythropoietin can increase clinical curative rate, improve the symptoms and biochemical indexes in patients with uremic anemia without severe adverse re-actions.关键词
尿毒症贫血/谷胱甘肽/促红细胞生成素Key words
Uremia anemia/Glutathione/Erythropoietin
