北京中医药大学学报2016，Vol.39Issue(6)：480-488,9.DOI:10.3969/j.issn.1006-2157.2016.06.009
基于酚类成分特征图谱的女贞子质量表征研究
Quality representation and correlation analysis of Ligustrum lucidum Ait. based on characteristic spectrum of drug system
摘要
Abstract
Objective To establish qualityrep resentation and correlation analysis method of Ligustrum lucidum Ait.(Glossy Privet Fruit,Nüzhenzi)based on characteristic spectrum of drug system,so as to evaluate thequality of Nüzhenzi decoction pieces accurately and comprehensively.Methods Usinges-tablished HPLC-PDA method to represent the quality of Nüzhenzi characteristic spectrum of drug system. Then the qualitative representation of 14 batches of Nüzhenzi decoction pieces was based on the quantity and type of characteristic peaks of specific chromatograms,the quantitative representation of 14 batches of Nüzhenzi pieces was based on the content of four characteristic index components including salidroside, tyrosol,specnuezhenide and quercetin and the sum of iridoids (using specnuezhenide for representation)and flavonoids (using quercetin for representation ), then correlation analysis was based on the representation results of quantity and quality respectively in 14 batches of Nüzhenzi pieces referenced to thebenchmarkdecoctionpiece.Results TakingLot.S10as the benchmark,in Nüzhenzi HPLCspecific chromatogram there were 1 1 characteristic peaks which were common in all batches,including two benzene glycosides peaks ,five iridoids peaks,four flavonoids peaks.The contents of effective index components in batch S14,S12,S5,S8,S9,S6 and S11 were higher,with the highest correlation in S14, S12,S5,S8,S9 and S10,so the quality of S5,S8,S9,S12,and S14 were superior to other batches. Conclusion The evaluation model of qualityrep resentation and correlation analysis of Nüzhenzispecific chromatogram concerning on correlation of the overall quality and the effectiveness of the application,can effectively and accurately evaluate the quality of Nüzhenzi.关键词
女贞子/特征图谱/质量表征/红景天苷/酪醇/特女贞苷/槲皮素Key words
Nüzhenzi/characteristic spectrum/quality representation/salidroside/tyrosol/specnu-ezhenide/quercetin分类
医药卫生引用本文复制引用
赵丽敏,石任兵,卢广英,杨书娟,许舒娅,彭平,李钢,李焕娟,冯朵,阳长明..基于酚类成分特征图谱的女贞子质量表征研究[J].北京中医药大学学报,2016,39(6):480-488,9.基金项目
十二五国家科技支撑计划项目（No．2012BAI29B06），北京中医药大学创新团队资助项目 （）
