磁共振成像2016，Vol.7Issue(6)：401-406,6.DOI:10.12015/issn.1674-8034.2016.06.001
脑卒中静息态下脑活动异常的比率低频振幅fMRI研究
A fractional amplitude of low frequency fluctuation study of resting-state fMRI in stroke
摘要
Abstract
Objective:To investigate the abnormal changes in baseline brain activity of the chronic stroke patients by using fractional amplitude of low frequency fluctuation(fALFF)ofresting-statefMRI.Materials and Methods:Sixteenchronic stroke patients with left subcortical lesions and sixteen age and sex-matched healthy volunteers were performed resting-state fMRI scans. Values of fALFF were calculated in the frequency ranging from 0.01–0.08 Hz. Two-sample t-test was performed to compare the differences in fALFF between the two groups (P<0.05, corrected by AlphaSim). Results:Compared with the healthy controls, the areas where the fALFF values decreased in stroke patients mainly located in the ipsilesional thalamus and basal ganglia, of which, the fALFF values of the ipsilesional thalamus showed significantly positive correlation with the Fugl-Meyer Assessment (FMA) scores in stroke patients (r=0.54, P=0.03<0.05). Conclusion:The abnormal spontaneous neural activity of the stroke is closely related to lesions site and hand motor dysfunction. These findings help us to further understand the pathophysiological mechanisms of the motor dysfunction in stroke.关键词
脑卒中/功能磁共振成像/低频振幅Key words
Stroke/Magneticresonance imaging,functional/Frequency amplitude分类
医药卫生引用本文复制引用
王想敏,赵智勇,尹大志,孙莉敏,郑晓慧,贾杰,范明霞..脑卒中静息态下脑活动异常的比率低频振幅fMRI研究[J].磁共振成像,2016,7(6):401-406,6.基金项目
国家自然科学基金面上项目(编号81471651)；国家自然科学基金青年项目(编号81401859)；国家科技部“十二五”支撑计划项目(编号2013BAI 10B03)@@@@ACKNOWLEDGMENTS This work was part of National Natural Science Foundation of China (No.81471651) （编号81471651）
National Natural Science Foundation of China (No.81401859) and the 12th Five-Year Plan supporting project of Ministry of Science and Technology of the People's Republic of China (No.2013BAI10B03) （No.81401859）
