重庆医学2016，Vol.45Issue(16)：2202-2204,2208,4.DOI:10.3969/j.issn.1671-8348.2016.16.013
老年结直肠癌血清可溶性细胞间黏附分子-1及炎性因子表达的临床意义
Expression of soluble intercellular adhesion molecule-1 and inflammatory factor in elderly patients with colorectal carcinoma
摘要
Abstract
Objective To investigate the clinical significance of soluble intercellular adhesion molecule‐1 and inflammatory factors (CRP ,IL‐17) in elderly patients with colorectal carcinoma .Methods The expression of sICAM‐1 ,CRP and IL‐17 in 76 ca‐ses of elderly patients and 32 cases of youg patients with colorectal cancer were detected by enzyme linked immunosorbent assay be‐fore and after surgery ,and to analyze its clinical significance correlated with pathological parameters .Meanwhile ,60 cases of healthy were controls .Results The serum levels of IL‐17 and sICAM‐1 were higher in patients with different ages of colorectal cancer than those of the normal control group (P<0 .05) ,and the concentrations of the two group after operation were significantly lower than those of the normal control group (P<0 .05) .The CRP levels of the young group and old group were similar to that of the normal control group (P>0 .05) .The level of CRP before operation in the young group was higher than that in the normal control group (P<0 .05) .The levels of serum IL‐17 and sICAM‐1 were significantly different between the young and the old group(P<0 .05) , while the CRP level was similar in the two groups (P>0 .05) .The serum levels of sICAM‐1 and IL‐17 in colorectal cancer patients were associated with the degree of differentiation ,depth of invasion ,lymph node metastasis and TNM staging (P<0 .05) .The level of CRP was significantly correlated with the depth of invasion ,lymph node metastasis and TNM staging (P<0 .05) .Conclusion The serum levels of sICAM‐1 ,CRP and IL‐17 reflect the invasion and metastasis of colorectal cancer in a certain extent ,which play important roles in predicting the development and prognosis of colorectal cancer .关键词
结直肠肿瘤/细胞黏附分子/肿瘤分期/可溶性细胞间黏附分子/C反应蛋白/白细胞介素Key words
colorectal carcinoma/cell adhesion molecule/tumor staging/soluble intercellular adhesion molecules/C reactive pro tein/interleukin分类
医药卫生引用本文复制引用
陈翔,陆宝华,袁杰,江伟廷,梁发东,钮静,曾小兵..老年结直肠癌血清可溶性细胞间黏附分子-1及炎性因子表达的临床意义[J].重庆医学,2016,45(16):2202-2204,2208,4.基金项目
上海市宝山区科学技术委员会科研项目（E-12-18）；上海市宝山卫生青年医学人才培养项目（bswsyq-2015-A10）。 （）
