重庆医学2016，Vol.45Issue(16)：2215-2216,2219,3.DOI:10.3969/j.issn.1671-8348.2016.16.017
PRM 2 G398C多态性与386例汉族男性生育力的相关性研究
Association study of PRM2 gene polymorphism with male infertility in the 386 Chinese Han population
摘要
Abstract
Objective To determine the association of one single nucleotide polymorphism loci G 398C in PRM2 with male in‐fertility in Chinese Han population .Methods A total of 386 infertile men were recruited as the observation group and 255 fertile men were recruited as the control group .Routine semen analysis as well as sperm functional parameters such as DNA integrity and nucleoprotein maturity rates were analyzed .Direct sequencing of G398C in PRM2 gene of infertile and fertile men was also conduc‐ted to evaluate the association of G398C SNP loci with male infertility .Results Statistical analysis showed that the frequencies of CC genotype of PRM2 G398C was significantly different between the infertile (11 .92% ) and fertile men (6 .67% ) and it was asso‐ciated with increased risk of male infertility (OR= 2 .002 ,95% CI= 1 .097 -3 .653 ,P< 0 .05) .Moreover ,it was discovered that sperm DNA integrity as well as nucleoprotein maturity rate of CC genotype were dramatically decreased compared with other geno ‐types (P<0 .05) ,which would probably lead to infertility .Conclusion Our results gave the first evidence that PRM 2 G398C poly‐morphism was associated with male infertility in Chinese Han population .关键词
鱼精蛋白2/多态性 ,单核苷酸/不育 ,男(雄)性/遗传易感性Key words
protamine 2/polymorphism ,single nucleotide/infertility ,male/genetic susceptibility分类
医药卫生引用本文复制引用
李俊,刘芳,杨雪梅,宋亚曼,冯艳萍,谭宇哲..PRM 2 G398C多态性与386例汉族男性生育力的相关性研究[J].重庆医学,2016,45(16):2215-2216,2219,3.基金项目
河北省人口和计划生育委员会指令课题（2013-A08）。 （）
