重庆医学2016，Vol.45Issue(17)：2312-2313,2318,3.DOI:10.3969/j.issn.1671-8348.2016.17.003
缺氧调控 JAR 细胞 Stat3表达及细胞凋亡的研究
The effects of hypoxia on the expression of Stat3 and the cell apoptosis
摘要
Abstract
Objective To investigate the effects of hypoxia on the expression of Stat3 and p-Stat3 ,and assessed the apoptosis ability of JAR cells in vitro .Methods JAR cells were cultured under hypoxic conditions .Western blot were used to determine the protein expression of Stat3 and p-Stat3 .Cellular apoptosis was monitored by flow cytometry analysis .Results Abnormal morpholo-gy changes in trophoblast cells under low oxygen conditions .After 48 h hypoxic treatment ,the protein of Stat3 and p-Stat3 were significantly decreased(P< 0 .05) ;however ,the level of apoptosis was significantly increased (P < 0 .05) .Conclusion Stat3 and p-Stat3 protein levels were decreased under hypoxia circumstance ,while the cell apoptosis ability was increased in JAR cells .关键词
细胞信号转导子和转录激活子 3/缺氧/滋养细胞/凋亡Key words
signal transducer and activator of transcriptions 3/hypoxia/trophoblast/apoptosis分类
医药卫生引用本文复制引用
杜尚珂,石瑛,岳宁,张琳琳,于海洋,贾莉婷,张展..缺氧调控 JAR 细胞 Stat3表达及细胞凋亡的研究[J].重庆医学,2016,45(17):2312-2313,2318,3.基金项目
河南省科技创新人才计划项目（124200510005）。 （）
