重庆医学2016，Vol.45Issue(17)：2365-2366,2369,3.DOI:10.3969/j.issn.1671-8348.2016.17.020
艾滋病热毒蕴结证的 miRNA 差异表达研究
Research of miRNA differential expression of AIDS with the syndrome of heat-toxic accumulation
姜岑 1曹春辉 2李白雪 1冯全生1
作者信息
- 1. 成都中医药大学基础医学院 610075
- 2. 重庆市中医院 400011
- 折叠
摘要
Abstract
Objective The Study the difference of miRNA expression of AIDS patients with toxic heat accumulation syn -drome with healthy control group .Methods This research used Agilent miRNA chip to test the miRNA of blood preparation ,and used SAS system to screen the differences between groups ,then analyzed the significance function of target gene .Results Compare the heat-toxic accumulation group and the healthy control group ,100 cases of obvious expression difference and of which the differ-ence was 2 times and greater were screened out (in which 64 cases showed up-regulation and 36 showed down-regulation) .Differen-tially expressed miRNAs function involves the role of IL-21 receptor in T cell activation ,C reactive protein ,and the positive regula-tion of the immune response .Conclusion AIDS toxic heat accumulation syndrome patients and healthy control groups exist differ -ences in miRNA expression profiles ,the biological basis of syndrome maybe related to T cell activation and IL-21 receptor .关键词
获得性免疫缺陷综合征/热毒蕴结证/miRNA/靶基因Key words
AIDS/heat-toxic accumulation/miRNA/target gene分类
医药卫生引用本文复制引用
姜岑,曹春辉,李白雪,冯全生..艾滋病热毒蕴结证的 miRNA 差异表达研究[J].重庆医学,2016,45(17):2365-2366,2369,3.
