重庆医学2016，Vol.45Issue(18)：2457-2459,3.DOI:10.3969/j.issn.1671-8348.2016.18.003
还原型谷胱甘肽对微囊藻毒素-LR染毒小鼠肝脏抗氧化功能的影响
Effect of glutathione on liver antioxidative function of microcystin-LR-induced mice
摘要
Abstract
Objective To study the effect of glutathione(GSH)on liver antioxidative function of microcystin‐LR(MC‐LR)‐in‐duced mice .Methods Forty healthy clean class KM 5‐week old mice were selected and divided into five groups by the random sam‐pling method ,including the norml saline control group ,GSH control group ,MC‐LR group ,MC‐LR+low dose GSH group and MC‐LR+high dose GSH group ,8 cases in each group ,half male and half female .The experiment lasted for 15 d by intraperitoneal injec‐tion of MC‐LR ,then the liver histopathological changes ,liver tissue activity of superoxide dismutase (SOD) ,glutathione peroxidase (GSH‐Px)and content of malondialdehyde(MDA) were detected .Results Compared with the normal saline control group ,liver cell GSH level ,SOD and GSH‐Px activities in the MC‐LR group were significantly decreased (P<0 .05) ,while the MDA level was sig‐nificantly increased (P<0 .05) .Compared with the MC‐LR group ,the GSH level ,SOD and GSH‐Px activities in the MC‐LR+low dose GSH group and MC‐LR+high dose GSH group were significantly increased (P<0 .05) ,while the MDA level was significant‐ly decreased(PP<0 .05) .Conclusion The GSH intervention can alleviate MC‐LR induced mouse liver oxidative toxicity and has protective effect on the liver to some extent .关键词
微囊藻毒素类/谷胱甘肽/抗氧化功能Key words
microcystin/glutathione/antioxidative function分类
医药卫生引用本文复制引用
韩知峡,杨婷,张春莲,熊伟,张青碧..还原型谷胱甘肽对微囊藻毒素-LR染毒小鼠肝脏抗氧化功能的影响[J].重庆医学,2016,45(18):2457-2459,3.基金项目
四川省卫生厅自然科学基金资助项目（120384）；泸州医学院大学生科研项目（2012075）。 （）
