重庆医学2016，Vol.45Issue(18)：2482-2483,2.DOI:10.3969/j.issn.1671-8348.2016.18.010
特应性皮炎Th1／Th2／Th17平衡的研究
Study on Th1/Th2/Th17 balance in atopic dermatitis
摘要
Abstract
Objective To research the change rule of peripheral serum Th1/Th2/Th17 balance and relevant cytokines in atopic dermatitis(AD) and to further study its immunologic mechanism .Methods The levels of peripheral serum IFN‐γ,IL‐4 ,IL‐17 ,IL‐21 and IL‐23 in the patients with AD were detected by the flow immunofluorescence technology and the detection results were performed the statistical analysis ,thus the change rule of Th1/Th2/Th17 balance in AD was analyzed .Results The IL‐4 level in peripheral serum of the patients with AD was increased compared with the healthy control group (P<0 .05);the IFN‐γ/IL‐4 and IFN‐γ/IL‐17 in the AD group were significantly decreased compared with the control group (P<0 .01);IL‐17 was positively corre‐lation with SCORAD scores of AD severity (P<0 .05) .Conclusion Th1/Th2 and Th1/Th17 are decreased in the AD course .Th1/Th2/Th17 balance drift may be the important mechanism of AD pathogenesis .关键词
特应性皮炎/细胞因子类/Th1细胞/Th2细胞/Th17细胞/流式荧光技术Key words
atopic dermatitis/cytokines/Th1 cells/Th2 cells/Th17 cells/flow immunofluorescence technology分类
医药卫生引用本文复制引用
蒋有让,刁庆春,史丙俊,王樱霖,徐可佳,冯林..特应性皮炎Th1／Th2／Th17平衡的研究[J].重庆医学,2016,45(18):2482-2483,2.基金项目
重庆市卫生局中医科研计划立项目录（2011-2-102，2012-2-182）；重庆市自然科学基金资助项目（cstc 2012jjA 10141）。 （）
