重庆医学2016，Vol.45Issue(18)：2522-2525,4.DOI:10.3969/j.issn.1671-8348.2016.18.023
血液透析联合血液灌流与 HDF治疗尿毒症患者皮肤瘙痒的Meta分析
Hemodialysis combined with hemoperfusion versus hemodialysis combined with hemodiafiltration in treating uremic pruritus：a meta analysis
摘要
Abstract
Objective To investigate the clinical efficacy of hemodialysis (HD) combined with hemoperfusion (HP) versus HD combined with hemodiafiltration(HDF) in treating uremic pruritus .Methods The randomized controlled trials(RCTs) on HD combined HP versus HDF in treating uremic pruritus were retrieved from the electronic databases of Cochrane library ,PubMed , Science ,CNKI ,Chinese Biological Medicine ,Wanfang and CNKI by computer .The domestic medical journals ,monographs ,meeting documents and academic dissertations were manually retrieved .The retrieval time limit was from their establishment to October 2015 .Meanwhile the obtained reference literature indexes were consulted .The two researchers independently screened the collected literatures according to the formulated inclusion and exclusion standards .The visual analogue scale (VAS) ,skin itchy effect judg‐ment criteria ,Dirk R Kuypers score ,PTH ,Ca2+ and P3 - were adopted as the evaluation standards .The Review Manager 5 .3 soft‐ware was used to conduct the meta‐analysis .Results Nine RCTs were finally included ,involving 405 patients .The meta analysis showed that HD+ HP had better effect than HD+ HDF in treating uremic pruritus and clearing blood BUN ,HD+ HDF had better effect than HD+ HP for maintaining Scr and P3 - clearing effect ,while no statistically significant difference was found in terms of PTH decrease and Ca2+ influence (P>0 .05) .Conclusion The dialysis mode of HD+ HP is more effective in treating uremic pruri‐tus .关键词
肾透析/血液灌流/皮肤瘙痒/血液透析滤过/M eta分析Key words
renal dialysis/hemoperfusion/pruritus/hemodiafiltration/meta analysis分类
医药卫生引用本文复制引用
唐倩,蒋先淑,李志勇..血液透析联合血液灌流与 HDF治疗尿毒症患者皮肤瘙痒的Meta分析[J].重庆医学,2016,45(18):2522-2525,4.基金项目
重庆市卫生局医学科研计划项目（2011-2-286，2012-2-155）。 （）
