动物医学进展2016，Vol.37Issue(5)：77-81,82,6.
肌肉生长抑制素对骨骼肌作用研究进展
Progress on Effects of Myostatin on Skeletal Muscle
摘要
Abstract
Myostatin(MSTN),also known as growth differentiation factor 8 (GDF-8),is a member of transforming growth factor beta (TGF-beta)super family.MSTN is mainly expressed in skeletal muscle as well as other tissues including cardiac muscle,fat,breast,and plays significant roles in inhibiting growth and development of skeletal muscle and inducing muscle atrophy.Recent studies have shown that MSTN may act synergistically on skeletal muscle in different ways.MSTN inhibits proliferation and dif-ferentiation of muscle cells by activating TGF-beta,p38MAPK,ERK1/2,and JNK signaling pathways and IGF-AKT and Wnt signaling pathways,influences synthesis and decomposition of skeletal muscle pro-tein by negative regulation of AKT pathway and regulation of the ubiquitin protease activity and autoph-agy-lysosome system.MSTN also participates in fat metabolism and physiological activities,such as bone formation,related to the generation of skeletal muscle.In this paper,starting with the signaling pathways MSTN acts on,we reviewed the effects of MSTN on proliferation and differentiation of muscle cells,syn-thesis and decomposition of muscle protein,fat metabolism,and skeletal development,and also summa-rized the application prespects of MSTN in order to provide references for further studies.关键词
肌肉生长抑制素/骨骼肌/肌细胞/作用机制Key words
myostatin/skeletal muscle/muscle cell/action mechanism分类
农业科技引用本文复制引用
杨惠,额尔敦木图,姜建强,包花尔,那仁巴图,刘图雅..肌肉生长抑制素对骨骼肌作用研究进展[J].动物医学进展,2016,37(5):77-81,82,6.基金项目
内蒙古自治区科技计划资助项目 （）
