动物营养学报2016，Vol.28Issue(5)：1285-1293,9.DOI:10.3969/j.issn.1006-267x.2016.05.001
沉默信息调节因子1对脂类代谢的调控作用
Regulation of Silent Information Regulator 1 on Lipid Metabolism
摘要
Abstract
Silent information regulator 1 ( SIRT1 ) can inhibit the transcription activity of lipogenic⁃related genes peroxisome proliferator⁃activated receptors gamma ( PPARγ) and sterol regulatory element binding factor 1 c ( SREBP1c) through the deacetylation, resulting in inhibiting anabolism of lipid and promoting catabolism. In addition, SIRT1 reduces lipid anabolism, accelerates lipolysis and reduces fat deposition, which may be as⁃sociated with regulating the SIRT1⁃adenosine 5′⁃monophosphate⁃activated protein kinase ( AMPK) and SIRT1⁃mammalian target of rapamycin ( mTOR) signaling pathways. This review summarizes the regulation of SIRT1 on animal lipid metabolism via related transcription factors and signaling pathways, which provides the basis for the further investigation of animal lipid metabolism and improving meat quality.关键词
沉默信息调节因子1/脂类代谢/转录因子/信号通路Key words
silent information regulator 1/lipid metabolism/transcription factors/signaling pathway分类
农业科技引用本文复制引用
吴铁梅,闫素梅,格日乐玛..沉默信息调节因子1对脂类代谢的调控作用[J].动物营养学报,2016,28(5):1285-1293,9.基金项目
国家公益性行业（农业）科研专项经费 （）
