动物营养学报2016，Vol.28Issue(5)：1309-1316,8.DOI:10.3969/j.issn.1006-267x.2016.05.004
乳腺内氨基酸调控乳蛋白合成的分子作用机制
Molecular Mechanisms in Regulation of Milk Protein Synthesis by Amino Acids in Mammary Gland
摘要
Abstract
As an important ‘biological factory’ to maintain life activities of mammalian, the mammary gland utilizes nutrients, such as amino acids, that uptake from blood as substrates to synthesize milk protein. Studies confirmed that amino acids also can be used as a signal factor to regulate milk protein gene transcription and translation through the signaling cascade pathways in the mammary gland, which affects milk protein synthesis. Janus kinase⁃signal transducer and activator of transcription ( JAK⁃STAT) and mammalian target of rapamycin ( mTOR) signaling pathways are the main regulatory pathways in the process of milk protein gene transcription and translation. The molecular mechanism of the JAK⁃STAT and mTOR signaling pathways in the mammary gland and research progress on regulation of milk protein synthesis by amino acids through these pathways were reviewed in this paper, with the aim to further clarify the mechanism in regulation of milk protein synthesis by amino acids.关键词
氨基酸/乳蛋白/调控/JAK-STAT/mTORKey words
amino acid/milk protein/regulation/JAK-STAT/mTOR分类
农业科技引用本文复制引用
张牧臣,高海娜,赵圣国,王珊珊,郑楠,王加启..乳腺内氨基酸调控乳蛋白合成的分子作用机制[J].动物营养学报,2016,28(5):1309-1316,8.基金项目
现代农业产业技术体系专项资金（ nycytx-04-01）；中国农业科学院科技创新工程 （）
