国际妇产科学杂志2016，Vol.43Issue(3)：267-271,5.
坤泰胶囊和激素替代治疗围绝经期综合征患者的有效性及安全性荟萃分析
Meta Analysis of Efficacy and Safety between Kuntai Capsule and Hormone Replacement Therapy for Patients with Perimenopausal Syndrome
杜晓琴 1衡明莉 2徐玲1
作者信息
- 1. 300100 天津市中心妇产科医院
- 2. 天津市中医药大学
- 折叠
摘要
Abstract
Objective:To evaluate the efficacy and safety between Kuntai capsule and hormone replacement in treating patients with perimenopausal syndrome. Methods:Such databases as the Cochrane Library, PubMed, CNKI, VIP and Wanfang Data and others were electronically searched. A systemic review and meta-analysis of publication from November 2004 to February 2015 was performed. The review was limited to randomized controlled trials that compared Kuntai capsule and hormone replacement therapy in treatment of perimenopausal syndrome and therapy period was at least 3 months. The primary outcome assessed was the efficacy at 3 month-time point,including the effective rate of Kupperman Menopausal Scores,blood E2 and FSH level. Safety index mainly includes the incidence of adverse reactions (such as gastrointestinal complains,breast distending pain or vaginal bleeding,etc). Results:Fifteen studies,including 1 243 total participants were included. The total effective rate and change of blood FSH level showed no significant difference between Kuntai capsule group and the hormone replacement therapy group (P>0.05). The Kupperman Menopausal Scores and blood E2 level in the hormone replacement therapy group were higher than Kuntai capsule group (P<0.05). Adverse reaction,such as gastrointestinal complains,breast distending pain or vaginal bleeding,Kuntai capsule group was inferior to hormone replacement therapy group in terms of adverse reactions (P<0.05). Conclusions:The current limited evidence showed that, Kuntai capsule could also improve climacteric symptoms and reduce the incidence of adverse reaction.关键词
坤泰胶囊/激素替代疗法/围绝经期/药物疗法/Meta分析Key words
Kuntai capsule/Estrogen replacement therapy/Perimenopause/Drug therapy/Meta-analysis引用本文复制引用
杜晓琴,衡明莉,徐玲..坤泰胶囊和激素替代治疗围绝经期综合征患者的有效性及安全性荟萃分析[J].国际妇产科学杂志,2016,43(3):267-271,5.
