国际妇产科学杂志2016，Vol.43Issue(3)：274-278,5.
妊娠寨卡病毒感染对胎儿脑/神经系统发育的影响
The Effects of Zika Virus Infection on Fetal Brain and Nervous System Development during Pregnancy
陈嘉雯 1任泰 1倪云翔 2丁之德3
作者信息
- 1. 200025 上海交通大学医学院临床医学系2012级临床八年制
- 2. 上海交通大学医学院附属同仁医院妇产科
- 3. 200025 上海交通大学医学院解剖学与组织胚胎学系
- 折叠
摘要
Abstract
In recent years, the Zika virus outbreak is ongoing in South-America, followed by increasing morbidity of neurological disorders, including Guillain-Barré syndrome and congenital microcephaly. By the end of March, 2016, thirty-three countries in America were involved, with suspected cases over 190 000. Besides, imported cases have also been reported in Europe and Asia. The correlation between Zika virus infection during the pregnancy and fetal neurogenesis defects raises global severe concern immediately. The potential mechanism can be divided into two pathways:①The blood-placenta barrier may be penetrated by Zika virus and the virus has a characteristic of neurotropism. Subsequently Zika virus can impair neurogenesis directly. ②Zika virus might disrupt fetal neurogenesis indirectly by other mediators, such as fetal inflammatory cytokines or antibodies in cross-immune response. Although the precise mechanism has not been completely elucidated yet, to review the effects of Zika virus infection in pregnancy on fetal neurogenesis promptly as well as the prevention and control of Zika virus outbreak in our country will have both critical clinical and long-term social significances.关键词
小头畸形/孕妇/胎儿/胎儿发育/格林-巴利综合征/黄病毒属/寨卡病毒Key words
Microcephaly/Pregnant women/Fetus/Fetal development/Guillain-Barre Syndrome/Flavivirus/Zika virus引用本文复制引用
陈嘉雯,任泰,倪云翔,丁之德..妊娠寨卡病毒感染对胎儿脑/神经系统发育的影响[J].国际妇产科学杂志,2016,43(3):274-278,5.
