医学分子生物学杂志2016，Vol.13Issue(3)：173-177,5.DOI:10.3870/j.issn.1672-8009.2016.03.010
KDMs参与恶性肿瘤细胞上皮间质转化
Histone Lysine Demethylases (KDM) Are Involved in the Epithelial-Mesenchymal Transition of Malignant Tumor Cells
摘要
Abstract
Metastasis is responsible for the poor prognosis of patients with malignant tumors. Epithelial⁃mesenchymal transition ( EMT) is a complex process, which regulates the cell morphology and function during embryogenesis and tissue development. It plays an important role in tumor metastasis. It is known that gene expression is regulated by epigenetic modifications, inclu⁃ding histone methylation. Histone demethylases regulate gene expression through demethylating mono⁃, di⁃, or tri⁃methylated lysine. Accumulating studies show that histone lysine demethylases ( KDMs) play a pivot role in the regulation of EMT⁃related genes. This paper reviews the recent ad⁃vances of KDMs in the EMT process of human malignant tumors.关键词
恶性肿瘤/上皮间质转化/表观遗传学/组蛋白去甲基化酶/组蛋白赖氨酸去甲基化酶Key words
malignant tumor/epithehal-mesenchymal transition (EMT)/epigenetics/his-tone demethylase/histone lysine demethylase分类
医药卫生引用本文复制引用
马丽丽,李玉凤,张景华..KDMs参与恶性肿瘤细胞上皮间质转化[J].医学分子生物学杂志,2016,13(3):173-177,5.基金项目
唐山市科技局科技指导项目（No．13130262a）This work was supported by a grant from the Tangshan Science and Tech-nology Bureau of Hebei Province of China （）
