临床与病理杂志2016，Vol.36Issue(6)：847-851,5.DOI:10.3978/j.issn.2095-6959.2016.06.023
凝血因子Ⅺ--抗血栓形成的新靶点
Coagulation factor Ⅺ：a new target for antithrombotic drug
刘惠娜(综述) 1邓常清 1贺石林(审校)2
作者信息
- 1. 湖南中医药大学血管生物学实验室，长沙 410208
- 2. 中南大学湘雅医学院生理学系，长沙 410008
- 折叠
摘要
Abstract
In recent years, the incidence of thrombotic diseases is increasing, which is seriously harmful to human health. Existing clinical applications of anticoagulants can cause severe bleeding complications. Recent studies indicate that FⅪ-deifcient mice were fully protected from occlusive thrombus without severely prolonged bleeding times. hTe study of antithrombotic therapy by inhibiting of FⅪ has made remarkable progress. On the basis of FⅪ, a new target for antithrombotic drug, this paper reviews the effect of FⅪ on thrombus formation and the recent progress on FⅪ for antithrombotic drug, and further wish to provide new strategy for development of new antithrombotic drug.关键词
血栓性疾病/凝血因子Ⅺ/抗血栓形成/新靶点Key words
thrombotic diseases/coagulation factor Ⅺ/anti-thrombus/a new target引用本文复制引用
刘惠娜(综述),邓常清,贺石林(审校)..凝血因子Ⅺ--抗血栓形成的新靶点[J].临床与病理杂志,2016,36(6):847-851,5.
