临床与病理杂志2016，Vol.36Issue(6)：852-858,7.DOI:10.3978/j.issn.2095-6959.2016.06.024
下丘脑黑皮质素系统对机体能量代谢的调控
Hypothalamic melanocortin system in the control of energy metabolism
摘要
Abstract
The hypothalamic melanocortin system represents the pivotal neural circuit in the central nervous system in the regulation of energy balance. Previous studies have reported its essential roles in the modulation of feeding behavior. Recent studies revealed the role and underlying mechanisms of this system in the regulation of glucose and lipid metabolism. Importantly, current evidence implied that melanocortin system, via sympathetic nervous system, enhances energy expenditure by promoting brown adipose tissue thermogenesis and browning/beige of white adipose tissues. In this review we will summarize recent discoveries on the hypothalamic melanocortin system and its associated neural circuit in the regulation of whole body energy homeostasis, we will also discuss the actions of current anti-obesity and anti-diabetes drugs in the central nervous system, in order to provide new insights for the treatment of obesity and diabetes.关键词
黑皮质素系统/能量代谢/产热/葡萄糖代谢Key words
melanocortin system/energy homeostasis/thermogenesis/glucose metabolism引用本文复制引用
黄梅凤(综述),胡芳(审校)..下丘脑黑皮质素系统对机体能量代谢的调控[J].临床与病理杂志,2016,36(6):852-858,7.基金项目
国家自然科学基金项目(31071921，31471131)，国家国际科技合作专项(2014DFG32490)，高等学校博士学科点专项科研基金(20100162120073)。hTis work was supported by the National Natural Science Foundation of China (31071921,31471131), International Science & Technology Cooperation Program of China (2014DFG32490), and Specialized Research Fund for the Doctoral Program of Higher Education (SRFDP)(20100162120073), P. R. China （31071921，31471131）
