海南医学院学报2016，Vol.22Issue(15)：1619-1622,4.DOI:10.13210/j.cnki.jhmu.20160427.002
丹红注射液对急性冠状动脉综合征患者介入治疗后内皮损伤、炎症反应程度及心功能的影响
Effect of danhong injection on endothel ial injury,degree of inflammation and cardiac function of patients with acute coronary syndrome after interventional therapy
摘要
Abstract
Objective:To analyze the effect of danhong injection on endothelial injury,degree of inflammation and car-diac function of patients with acute coronary syndrome after interventional therapy.Methods:A total of 104 patients with acute coronary syndrome who received inpatient treatment in our hospital from August 2012 to August 201 5 were chosen as the re-search subjects and randomly divided into observation group 52 cases and control group 52 cases according to different treat-ment.Control group received clinical routine interventional therapy for acute coronary syndrome,the observation group re-ceived danhong injection adjuvant treatment on the basis of interventional therapy,and then endothelial injury,the degree of in-flammation and cardiac function were compared between two groups.Results:After observation group received danhong injec-tion adjuvant treatment,plasma vWF,ET-1 and NTG value were lower than those of control group while NO and FMD value were higher than those of control group (P <0.05);serum pentraxin-3,IL-18,IL-18/IL-10 and LpPLA2 value of observation group after treatment were lower than those of control group while IL-10 value was higher than that of control group (P <0.05);LVEDV,LVESV and BNP value of observation group after treatment were lower than those of control group while LVEF value was higher than that of control group (P <0.05).Conclusions:Danhong injection adjuvant therapy on the basis of interventional therapy for patients with acute coronary syndrome can reduce vascular endothelial and inflammatory injury,and play a positive role in cardiac protection.关键词
急性冠状动脉综合征/介入治疗/丹红注射液/内皮损伤/炎症反应/心功能Key words
Acute coronary syndrome/Interventional therapy/Danhong injection/Endothelial injury/Inflammatory reaction/Cardiac function分类
医药卫生引用本文复制引用
刘洋,许金鹏,邸卫英,李靖,徐占稳,赵兴洲,宋书江,刘福林..丹红注射液对急性冠状动脉综合征患者介入治疗后内皮损伤、炎症反应程度及心功能的影响[J].海南医学院学报,2016,22(15):1619-1622,4.基金项目
河北省医学科学研究重点课题计划项目(07134) （07134）
