海南医学院学报2016，Vol.22Issue(15)：1653-1655,1659,4.DOI:10.13210/j.cnki.jhmu.20160415.010
初诊2型糖尿病应用西格列汀与二甲双胍治疗对血糖波动及微炎症状态的影响
Influence of sitgl iptin and metformin treatment on glucose fluctuation and serum inflammatory factors in prel iminary diagnosed type 2 diabetes mell itus
摘要
Abstract
Objective:To investigate the influence of stigliptin and metformin treatment on glucose fluctuation and ser-um inflammatory factors in preliminary diagnosed Type 2 diabetes mellitus.Methods:From January 2014 to December 201 5, 1 68 cases of patients with newly diagnosed Type 2 diabetes mellitus were recruited and divided randomly into observation group and control group.The observation group was given sitgliptin (Januvia,100 mg per d),while the control group was given met-formin (Glucophage tablet,initial dose 0.5 g bid,twice per d),and the dosage of drugs was adjusted every 2 weeks according to glucose level.If the glucose level still wasn't controlled to reach the normal standard by maximum dosage of drugs,0.5 g bid of acarbose (Glucobay)was applied for the treatment 3 times one day till the glucose level reached the normal standard and the observation was kept for 6 months.The HbA1c,BMI,fluctuation indexes,and serum inflammatory factors of two groups were compared.Results:After the treatment of control group and observation group,the differences of PPGE (t =8.425,P =0.012),MAGE (t =7.348,P =0.014)and MODD (t =9.327,P =0.010)between two groups were significant (P <0.05 ). The differences of IL-6 (t =6.337,P =0.010)and TNF-α(t =6.521,P =0.01 1)level of observation group and control group after treatment were statistical significant (P <0.05).Conclusions:The sitgliptin could not only achieve glycemic control goal as metformin,but also induce glucose fluctuation and inhibit serum inflammation better.关键词
2 型糖尿病/二甲双胍/西格列汀/血糖波动/微炎症状态Key words
Metformin/Sitgliptin/Type 2 diabetes mellitus/Glucose fluctuation/Microinflammatory state分类
医药卫生引用本文复制引用
向勤,吴逊..初诊2型糖尿病应用西格列汀与二甲双胍治疗对血糖波动及微炎症状态的影响[J].海南医学院学报,2016,22(15):1653-1655,1659,4.基金项目
重庆市卫生局科研资助项目(2011-2-469) （2011-2-469）
