海南医学院学报2016，Vol.22Issue(15)：1714-1717,1721,5.DOI:10.13210/j.cnki.jhmu.20160308.006
六君子汤联合 EP 化疗方案治疗晚期非小细胞肺癌的临床疗效评估
Cl inical efficacy of Liujunzi decoction combined with EP chemotherapy regiment on ad-vanced non-small cell lung cancer
摘要
Abstract
Objective:To analyze the clinical efficacy of Liujunzi decoction combined with EP chemotherapy regiment on advanced non-small cell lung cancer.Methods:A total of 72 patients with non-small cell lung cancer admitted from August 2012 to October 2014were included in the study.According to different treatment,they were divided into observation group 36 cases and control group 36 cases.Control group received EP chemotherapy,observation group received Liujunzi decoction combined with EP chemotherapy regiment,and then differences in serum tumor marker levels,tumor tissue-related protein levels,PD-CD5,Nrf2,HIF-1αand GLUT1 levels,and levels of VEGF,GSTs,TSGF and so on were compared between two groups.Re-sults:Serum CY21 1,SCC,NSE,CEA and CA1 99 levels of observation group after treatment were lower than those of control group (P <0.05 );TUBB3,ERCC-1,MT and P53 expression levels of observation group after treatment were lower while Mcll and Fbw7 expression levels were higher (P <0.05 );PDCD5 level of observation group after treatment was higher than that of control group while Nrf2,HIF-1αand GLUT1 levels were lower than those of control group (P <0.05);CD4 + CD25 +Foxp3 + Treg/CD4 + T,VEGF,GSTs and TSGF values of observation group after treatment were lower than those of control group (P <0.05).Conclusions:Liujunzi decoction combined with EP chemotherapy regiment for patients with advanced non-small cell lung cancer can effectively inhibit tumor cell proliferation as well as invasion and metastasis,is helpful for disease control and prognosis improvement,and has positive clinical significance.关键词
晚期非小细胞肺癌/EP 化疗/六君子汤Key words
Advanced non-small cell lung cancer/EP chemotherapy/Liujunzi decoction分类
医药卫生引用本文复制引用
熊新军,熊龙军..六君子汤联合 EP 化疗方案治疗晚期非小细胞肺癌的临床疗效评估[J].海南医学院学报,2016,22(15):1714-1717,1721,5.基金项目
孝感市科技局项目(2013xg06) （2013xg06）
