海南医学院学报2016，Vol.22Issue(15)：1745-1748,4.DOI:10.13210/j.cnki.jhmu.20160614.002
阿加曲班辅助治疗对急性脑梗死患者神经功能、内皮损伤、炎症状态的影响
Effect of adjuvant argatroban therapy on neurological function,endothel ial injury and inflam-mation state in patient with acute cerebral infarction
摘要
Abstract
Objective:To analyze the effects of adjuvant argatroban therapy on neurological function,endothelial injury and inflammation state in patient with acute cerebral infarction.Methods:A total of 1 18 patients with acute cerebral infarction were divided into observation group and control group according to the random number table,control group received conven-tional treatment,observation group received argatroban + conventional treatment,and then differences in TCD cerebral blood flow,serum neurological function,endothelial injury and inflammatory marker levels were compared between two groups after treatment.Results:TCD MCA and ACA values of observation group after treatment were higher than those of control group (P <0.05 );serum neurological function indexes copeptin,NT-proBNP,PAO and S-100B levels of observation group after treatment were lower than those of control group,endothelial injury index ET-1 level was lower than that of control group,NO and CGRP levels were higher than those of control group,and inflammatory markers hs-CRP,TNF-α,IL-6,MMP-9 and Lp-PLA2 levels were lower than those of control group (P <0.05).Conclusion:Adjuvant argatroban therapy can optimize the o-verall condition in patients with acute cerebral infarction,and plays a positive role in improving the neurological function,re-ducing endothelial injury and inflammation state,etc.关键词
急性脑梗死/阿加曲班/神经功能/内皮损伤Key words
Acute cerebral infarction/Argatroban/neurological function/Endothelial injury分类
医药卫生引用本文复制引用
车楠..阿加曲班辅助治疗对急性脑梗死患者神经功能、内皮损伤、炎症状态的影响[J].海南医学院学报,2016,22(15):1745-1748,4.基金项目
陕西省科技攻关项目资助课题(2006K13-G7) （2006K13-G7）
