海南医学院学报2016，Vol.22Issue(15)：1749-1751,3.DOI:10.13210/j.cnki.jhmu.20160503.001
阿托伐他汀联合脑心通胶囊治疗脑梗死患者颈动脉粥样硬化的临床分析
Effect of atorvastatin in combined with Naoxintong capsue on carotid atherosclerosis in pa-tients with cerebral infarction
摘要
Abstract
Objective:To explore the clinical efficacy of atorvastatin in combined with Naoxintong capsue in the treat-ment of carotid atherosclerosis (CAS)in patients with cerebral infarction.Methods:A total of 120 patients with cerebral infarc-tion merged with CAS who were admitted in our hospital from February,201 5 to February,201 6 were included in the study and randomized into the observation group and the control group.The patients in the control group were given bayaspirin, 100mg/time,before sleep,and atorvastatin,20 mg/time,at dinner.On this basis,the patients in the observation group were given Buchang Naoxintong capuse,4 capusles/time,3 times/d.Six-month treatment was regarded as one course.The full au-tomatic biochemical analyzer was used to the serum TC,TG,HDL-C,and LDL-C levels.The immunoturbidimetric assay was used to detect the serum CRP level.The color Doppler ultrasonic diagnosis apparatus was used to detect IMT and the plaque ar-ea.Results:After 6-month treatment,the levels of TC,TG,and LDL-C in the two groups were significantly reduced,while HDL-C was significantly elevated when compared with before treatment (P <0.05).The improvement of various indicators in the observation was significantly superior to that in the control group (P <0.05).After 6-month treatment,CRP level in the two groups was significantly reduced when compared with before treatment (P <0.05),and the reduced degree in the observa-tion group was significantly superior to that in the control group (P <0.05).After 6-month treatment,IMT and the plaque ar-ea in the two groups were significantly reduced when compared with before treatment (P <0.05),and the reduced degree in the observation group was significantly superior to that in the control group (P <0.05).Conclusions:The combined application of atorvastatin and Naoxintong capsule in the treatment of CAS in patients with cerebral infarction can effectively regulate the ser-um lipid level,reduce the inflammatory reaction,improve the atherosclerotic symptoms,and reduce the occurrence and recur-rence of cerebral infarction;therefore,it deserves to be widely recommended in the clinic.关键词
脑梗死/颈动脉粥样硬化/阿托伐他汀/脑心通胶囊Key words
Atorvastatin/Naoxintong capsule/Cerebral infarction/CAS分类
医药卫生引用本文复制引用
顾翠,胡嘉云,可秦,冯磊..阿托伐他汀联合脑心通胶囊治疗脑梗死患者颈动脉粥样硬化的临床分析[J].海南医学院学报,2016,22(15):1749-1751,3.基金项目
保山市科技计划项目(2014kj055) （2014kj055）
