海南医学院学报2016，Vol.22Issue(15)：1758-1760,3.DOI:10.13210/j.cnki.jhmu.20160415.003
碱性成纤维细胞生长因子联合激光对痤疮瘢痕创面中多种细胞因子含量的影响
Effect of basic fibroblast growth factor combined with laser on content of a variety of cyto-kines in acne scar wound
摘要
Abstract
Objective:To study the effect of basic fibroblast growth factor combined with laser on the content of a varie-ty of cytokines in acne scar wound.Methods:A total of 64 patients with facial acne scars who received laser treatment in Der-matology Department of our hospital from June 2012 to October 201 5 were studied and divided into two groups.Experimental group received collagen dressing combined with bFGF dressing change after surgery,and control group only received collagen dressing change after surgery.Wound healing as well as the content of type I collagen,type III collagen,TGF-β1,TAK and VEGF in the wound of two groups were compared.Results:Five days after surgery,the wound of experimental group had ap-parently scabbed and the scabby area was significantly greater than that of control group while the wound of control group showed visible granulation tissue proliferation and the scabby area was smaller;the levels of type I collagen,type III collagen, TGF-β1,TAK and VEGF in scab tissue of experimental group were significantly lower than those of control group.Conclu-sions:Basic fibroblast growth factor combined with laser can promote the healing of acne scar wound,decrease the type I colla-gen,type III collagen,TGF-β1 and VEGF content and prevent scar healing.关键词
痤疮瘢痕/碱性成纤维细胞生长因子/激光治疗/胶原Key words
Acne scar/Basic fibroblast growth factor/Laser/Collagen分类
医药卫生引用本文复制引用
董子瑄..碱性成纤维细胞生长因子联合激光对痤疮瘢痕创面中多种细胞因子含量的影响[J].海南医学院学报,2016,22(15):1758-1760,3.基金项目
2011年无锡市科技发展指导性计划项目(CSZ00N1135) （CSZ00N1135）
