解放军医药杂志2016，Vol.28Issue(6)：53-57,76,6.DOI:10.3969/j.issn.2095-140X.2016.06.013
急性单发性创伤性颅脑损伤与离子紊乱的相关性研究
A Correlation Study between Acute Isolated Traumatic Brain Injury and Electrolyte Disturbance
摘要
Abstract
Objective To analyze level changes of sodium,potassium,chloridion,magnesium and calcium ions in blood after acute isolated traumatic brain injury(TBI)and to study relationship between multiple electrolyte disturb-ance and TBI. Methods Clinical data of 158 patients with acute isolated TBI fitted to study criteria during July 2012 and June 2015 was retrospectively analyzed,and the patients were divided into severe injury group(n = 78,3-8 score of GCS),moderate injury group(n = 33,9-14 score of GCS)and mild injury group(n = 47,15 score of GCS)according to Glasgow Coma Scale(GCS)scores upon admission. The blood ionic concentrations upon admission were collected. In-dependent risk factors of ionic level reduction,relationships between mean value of serum ionic concentrations in groups and severity of acute isolated TBI,relationships between incidence rates of electrolyte disturbance in different ions and se-verity of acute isolated TBI and differences in constituent ratio of multiple electrolyte disturbance in groups after acute iso-lated TBI were analyzed using corresponding statistical methods. Results TBI severity,mid-line shift by CT examina-tion,cerebral contusion,subarachnoid hemorrhage and temporal lobe and cerebella injury were independent risk factors of ionic level reduction after acute isolated TBI(OR ﹥ 1,P ﹤ 0. 05). Serum concentration of sodium,potassium,chlo-ridion and magnesium were significant differences among three groups(rs ﹤ 0,P ﹤ 0. 05). There were significant differ-ences in incidence rate of electrolyte disturbance among three groups(P ﹤ 0. 05). Incidence rate of multiple electrolyte disturbance was significant different between severe injury group and mild and moderate injury groups(P ﹤ 0. 05). Inci-dence rates of combined reduction levels of serum sodium and magnesium,serum sodium,chloridion and magnesium,se-rum sodium and chloridion and serum sodium,potassium,magnesium and chloridion were high. Conclusion Severity of traumatic brain injury is closely correlated with multiple electrolytes disturbance. The multiple electrolytes disturbance is not only the evaluation index for severity of traumatic brain injury,but also induces brain damage. The monitoring of ser-um electrolytes is vital for diagnosis and treatment of patients with acute isolated traumatic brain injury.关键词
颅脑损伤/离子紊乱/危险因素Key words
Craniocerebral trauma/Electrolyte disturbance/Risk factors分类
医药卫生引用本文复制引用
包义君,陶山伟,李力卓,王鹏飞,张德威,黄小龙,赵丹,王维,王运杰..急性单发性创伤性颅脑损伤与离子紊乱的相关性研究[J].解放军医药杂志,2016,28(6):53-57,76,6.基金项目
教育部留学回国人员科研启动基金资助项目（教外司留［2013］1792号）；辽宁省自然科学基金面上项目（2015020460）；辽宁省自然科学基金（2013021083）；沈阳市科技创新专项基金-人口与健康科技攻关专项 （）
