解放军医药杂志2016，Vol.28Issue(6)：87-91,5.DOI:10.3969/j.issn.2095-140X.2016.06.022
参附注射液联合磷酸肌酸钠治疗扩张型心肌病心功能不全的疗效观察
Effect Observation on Shenfu Injection Combined with Creatine Phospate in Treatment of Cardiac Inadequacy of Patients with Dilated Cardiomyopathy
摘要
Abstract
Objective To investigate curative effect of Shenfu injection combined with Creatine Phospate in treatment of cardiac inadequacy of patients with dilated cardiomyopathy. Methods Clinical data of 72 patients with di-lated cardiomyopathy associated by cardiac inadequacy during January 2014 and June 2015 was retrospectively analyzed. The patients were divided into group A(n = 36)and group B(n = 36)according to different therapeutic methods. All patients received routine anti-heart failure therapy. Group A was treated with Shenfu injection combined with Creatine Phospate,while group B was injected with Creatine Phospate intravenously. Before treatment and 14 d after treatment, cardiac functional grading and 6-minute walking test(6MWT)were filled;Minnesota Living With Heart Failure Ques-tionnaire(MLHFQ)was also filled;serum B-type natriuretic peptide(BNP)levels and related parameters of left ventric-ular systolic function were detected;adverse reactions during treatment were statistically analyzed in the two groups. Re-sults Clinical symptoms in the two groups were alleviated 14 days after treatment,but the total effective rate in group A was higher than that in group B( P ﹤ 0. 05). Compared with those in group B,values of 6MWT distance and ejection fraction were higher(P ﹤ 0. 05);Values of MLHFQ score,serum BNP level,left ventricular end systolic and diastolic diameters were lower than those in group B(P ﹤ 0. 05). No obviously adverse reaction was found in two groups. Conclu-sion Shenfu injection combined with Creatine Phospate in treatment of cardiac inadequacy of patients with dilated car-diomyopathy can safely and effectively improve clinical symptoms and the quality of life.关键词
参附注射液/磷酸肌酸/心肌病,扩张型/利钠肽,B型Key words
Shenfu injection/Phosphocreatine/Cardiomyopathy,dilated/Natriuretic peptide,B-type分类
医药卫生引用本文复制引用
刘辉,王学惠,张少利,张小瑞,岳兵..参附注射液联合磷酸肌酸钠治疗扩张型心肌病心功能不全的疗效观察[J].解放军医药杂志,2016,28(6):87-91,5.基金项目
河南省科技发展计划 （）
