他汀应用于心房颤动防治的研究进展OA
Advances of research on statin’s application in atrial fibrillation control
心房颤动(atrial fibrillation,AF)是最常见的公共健康问题,研究显示炎症和心肌细胞氧化应激参与心房的结构重构和电重构,进而成为 AF 的潜在发病机制。他汀类药物是3-羟甲基-3-戊二单酰辅酶 A(HMG-CoA)还原酶抑制剂,除降脂外,兼有抗炎、抗氧化应激作用。他汀通过抗炎、抗氧化应激改善心房重构来降低 AF 的发病率。但是,在临床实践中,他汀的抗心律失常属性并未得到完全阐明,有关他汀在 AF 一级及二级预防中的结论备受争议。
Atrial fibrillation(AF)is the most common public health problem.It has been re-vealed by research that inflammation and oxidative stress of cardiac muscle cell involve in the struc-tural and electrical remodeling of atrium,which becomes the underlying pathogenesis of AF further-ly.Statins is a kind of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor.Besides the effi-cacy of lipid-lowering,statin drugs are also anti-inflammatory and anti-oxidative-st…查看全部>>
汪永生;张晓红
230061 安徽 合肥,合肥市第一人民医院心血管内科230061 安徽 合肥,合肥市第一人民医院心血管内科
医药卫生
心房颤动他汀炎症氧化应激
atrial fibrillationstatininflammationoxidative stress
《江苏实用心电学杂志》 2016 (3)
217-221,5
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