农药学学报2016，Vol.18Issue(3)：299-303,5.DOI:10.16801/j.issn.1008-7303.2016.0039
多杀菌素B的半合成制备方法
Semisynthesis of spinosyn B
摘要
Abstract
Spinosyn B bears very potent insecticidal acitivity. However, it is difficult to obtain because of its low concentration in natural. In this paper, spinosyn B was successfully synthesized from spinosyn A, the major component in spinosad, utilizing iodine, sodium acetate and sodium hydroxide as reagents and methanol as the solvent. After optimization, the yield has been improved to 81%. The structure of spinosyn B was confirmed by 1H NMR, 13C NMR and HRESI-MS.关键词
多杀菌素B/多杀菌素A/多杀菌素/合成/条件优化Key words
spinosyn B/spinosyn A/spinosad/synthesis/optimization分类
农业科技引用本文复制引用
赖青,欧晓明,裴晖,刘苏友,马大友..多杀菌素B的半合成制备方法[J].农药学学报,2016,18(3):299-303,5.基金项目
“十二五”国家科技支撑计划资助项目(2011BAE06B04-12)；国家自然科学基金资助项目(21472247) （2011BAE06B04-12）
