山东理工大学学报（自然科学版）2016，Vol.30Issue(5)：56-60,5.
预耐力训练预防急性酒精性肝损伤--肝脏抗氧化能力与线粒体解偶联关系的研究
The effect of pr-endurance training on relationship between mitochondrial antioxidant ability and uncoupling function in alcohol-induced acute hepatic inj ury rats
摘要
Abstract
To investigate the effect of pre-endurance training on the relationship between mito-chondrial antioxidant ability and uncoupling function in alcohol-induced acute hepatic inj ury rats. We analysised the expressions of UCP2,HDMCP and MnSOD mRNA,mitochondrial P/O,activ-ities of MnSOD and ATP synthase in liver tissue in alcohol-induced acute hepatic inj ury rats after 1 2 week unload swimming training.Acute alcohol treatment resulted in increased mRNA expres-sion of MnSOD,UCP2 and HDMCP but decreased P/O and ATP synthase activity.Compared with acute alcohol treatment of untrained rats,acute alcohol treatment of trained rats have lower expressions of UCP2 and HDMCP but higher P/O and mRNA expression of MnSOD.Pre-endur-ance training can increase liver antioxidant ability,decrease expression of uncoupling proteins, which increases liver mitochondrial ATP synthesis,and it achieves a prevention of acute alcohol-induced hepatic inj ury.关键词
预耐力训练/急性酒精性肝损伤/抗氧化能力/解偶联作用Key words
pr-endurance training/acute alcohol-induced hepatic inj ury/antioxidant ability/un-coupling function分类
社会科学引用本文复制引用
苏文,刘艳环,王漫卓,马国栋..预耐力训练预防急性酒精性肝损伤--肝脏抗氧化能力与线粒体解偶联关系的研究[J].山东理工大学学报（自然科学版）,2016,30(5):56-60,5.基金项目
山东理工大学青年学者支持计划(110026) （110026）
