山东医药2016，Vol.56Issue(24)：17-19,3.DOI:10.3969/j.issn.1002-266X.2016.24.005
SIRT1在结直肠癌组织中的表达及其与 MDR-1的关系
Expression of SIRT1 in colorectal carcinoma and its relationship with and MDR-1
摘要
Abstract
Objective To investigate the expression of silent information regulator 1 ( SIRT1) in colorectal carcinoma (CRC) and its relationship with and multidrug resistance-related protein 1 (MDR-1).Methods We used the imunohisto-chemistry method to detect the expression of SIRT 1 and MDR-1 and analyzed their relationships with clinical data in 162 specimens of CRC.Results SIRT1 and MDR-1 expression was detected in 107 (66.0%) and 96 (59.2%) out of 162 colorectal adenocarcinomas , respectively.Statistically, the expression of the SIRT1 protein was not associated with clinical and pathological parameters , including sex, tumor stage, lymph node metastasis and tumor differentiation (all P>0.05), but was associated with tumor size (P<0.05).In addition, the positive expression of SIRT1 and MDR-1 in CRC was posi-tively correlated with each other (r=0.506, P<0.01).Conclusion SIRT1 is highly expressed in the CRC and its ex-pression is positively correlated with MDR-1 expression.关键词
结直肠癌/沉默信息调节因子1/多药耐药相关蛋白1/免疫组织化学Key words
colorectal carcinoma/silent information regulator 1/multidrug resistance-related protein 1/immunohisto-chemistry分类
医药卫生引用本文复制引用
王静,崔敏,张骞,李红,张燕,曹璋..SIRT1在结直肠癌组织中的表达及其与 MDR-1的关系[J].山东医药,2016,56(24):17-19,3.基金项目
山东省自然科学基金资助项目（ZR2011HQ025，ZR2013HQ018）；滨州医学院科研启动基金（BY2010KYQD10，2013QNKJJ01）。 （）
