护理研究2016，Vol.30Issue(19)：2343-2348,6.DOI:10.3969/j.issn.1009-6493.2016.19.010
鼻咽癌病人同步放化疗前后身心适应状况及其相关因素
Physical and mental adaption status of patients with nasopharyngeal carcinoma before and after concurrent chemo-radiotherapy and its related factors
摘要
Abstract
Objective:To investigate the psychological adaptation and T lymphocyte function level in patients with nasopharyngeal carcinoma receiving concurrent chemoradiotherapy before and after treatment ,and to ana-lyze the correlation between level of psychological adaptation and function of T lymphocytes ,in order to provide basis for clinical psychological nursing work .Methods :A convenient sampling method was adopted to collect a total of 126 cases of nasopharyngeal carcinoma patients admitted to our hospital from October 2013 to April 2015 ,w ho met the inclusion and exclusion criteria and received the concurrent radiotherapy and chemotherapy . They were investigated by General Information Questionnaire ,Simple Cancer Patient Psychological Adaptation Questionnaire(Mini MAC 19) and Symptom Self Rating Scale(SCL 90) before and after treatment .At the same time ,before and after treatment ,the anti coagulation peripheral blood 2 ml was taken with aseptic tech-nique operation ,the CD3 ,CD4 and CD8 were measured by flow cytometry ,and correlation between psychological adaptation and immune parameters was analyzed .Results:Before concurrent chemoradiotherapy ,different ages of patients with nasopharyngeal carcinoma had different levels of psychological adaptation score ,and different in-come levels of patients had different CD3 and CD4 indicators ,there were statistically significant difference (both P<0 .05);after concurrent chemoradiotherapy ,SCL 90 score of patients with different marital status was dif-ferent ;different marital status of patients had different CD4 and CD8 indicators ,SCL 90 score was significantly lower than that of patients without gastric stoma in the patients with fistula ,and there were statistically signifi-cant difference(P<0 .05);before and after treatment ,the SCL 90 score and CD3 and CD4 were different(P<0 .05) . The total score of psychological adaptation was positively correlated with CD 3 (P<0 .05) .Conclusion:The phys-ical and psychological adaptation of nasopharyngeal carcinoma patients with different ages ,education levels and income levels should be paid attention to before the concurrent chemoradiotherapy ,and to pay attention to pa-tients with different marital status after treatment .There was a significant impact on the physical and psycho-logical status of the patients with concurrent chemoradiotherapy ,and patients had better psychological adapta-tion and T lymphocyte immune function after the treatment .关键词
鼻咽癌/放射治疗/化学治疗/心理行为/T淋巴细胞亚群Key words
nasopharyngeal carcinoma/radiotherapy/chemotherapy/psychological behavior/T lymphocyte subsets分类
医药卫生引用本文复制引用
柯熹,骆惠玉,陈秀梅,蒋梦媛,林丽,黄丽洁,刘雅清,杨华清..鼻咽癌病人同步放化疗前后身心适应状况及其相关因素[J].护理研究,2016,30(19):2343-2348,6.基金项目
福建省自然科学基金计划项目，编号2013J01287；国家临床重点专科建设项目（国卫办医函〔2013〕544号）。 （）
