天津工业大学学报2016，Vol.35Issue(3)：6-9,15,5.DOI:10.3969/j.issn.1671-024x.2016.03.002
相反转法制备聚乳酸载青藤碱微胶囊及其性能表征
Fabrication and characterization of PLA microcapsules loaded with sinomenine prepared by phase inversion method
摘要
Abstract
The PLA microcapsules loaded with sinomenine were successfully prepared by phase inversion method using methylene chloride as solvent, Span 80 and Tween 80 as emulsifier, gelatin as stabilizer. The properties of the microcapsules were characterized by scanning electron microscope, Fourier transform infrared spectrometer and particle size analyzer. Drug loading, encapsulation efficiency as well as drug release properties and targeted absorption effect were also determined. The results show that the microcapsules have smooth surface and the particle size is reduced with the increase of the emulsifier ratio. Drug loading and encapsulation efficiency reach the maximum when the emulsifier ratio is at 5%, and the maximum are 8.9%!and 89.2%, respectively. Also, the microcapsules have obviously sustained efficacy and targeting intestinal absorption features.关键词
相反转法/微胶囊/青藤碱/聚乳酸/缓释Key words
phase inversion method/microcapsules/sinomenine/polylacetic acid/sustained release分类
轻工纺织引用本文复制引用
张华,张凤,张雯,张喜悦..相反转法制备聚乳酸载青藤碱微胶囊及其性能表征[J].天津工业大学学报,2016,35(3):6-9,15,5.基金项目
国家自然科学基金资助项目（51573135、51203113）；天津市高等学校科技发展基金计划项目（20140305）；国家级大学生创新创业训练计划项目 （）
