中国组织工程研究2016，Vol.20Issue(27)：3963-3969,7.DOI:10.3969/j.issn.2095-4344.2016.27.002
不同运动强度干预2型糖尿病模型大鼠的骨密度变化
Different exercise intensities affect bone mineral density in type 2 diabetic rats
摘要
Abstract
BACKGROUND:More than 50% of patients with diabetes are accompanied by osteoporosis. Exercise is the main method to treat diabetes, but whether it has an impact on diabetes osteoporosis is unclear. <br> OBJECTIVE:To analyze the different exercise intensities and changes in bone mineral density in type 2 diabetic rat models. <br> METHODS:Forty rats were randomly divided into model group and low-, medium-and high-intensity exercise groups. Al rats received intraperitoneal injection of streptozotocin to establish models of type 2 diabetes. Rats in the low-, medium-and high-intensity exercise groups did treadmil training at 10, 20, 30 m/min, 1 hour per day, 6 daysas a cycle. They had a rest for 1 day after each cycle, for 8 consecutive cycles. Rats in the model group did not do any exercise. <br> RESULTS AND CONCLUSION:Compared with the model group, the weight of rats was decreased; blood glucose levels were reduced;osteocalcin and serum calcium levels and biomechanical indexes of femur increased; serum phosphorus and alkaline phosphatase decreased in the low-, medium-and high-intensity exercise groups. Bone mineral density increased in the medium-and high-intensityexercise groups. These findings confirmed that different exercise intensitieshavea certain influence on bone mineral density and bone metabolism in type 2 diabetic rat models. When using a method of treating movement, proper physical exercise can increase serum osteocalcin content, improve bone metabolism, prevent diabetic osteoporosis, and have a high clinical value.关键词
实验动物/骨软骨损伤与修复动物模型/运动强度/2型糖尿病/骨密度/骨质疏松症/骨钙素/生物力学/骨代谢分类
医药卫生引用本文复制引用
江洪..不同运动强度干预2型糖尿病模型大鼠的骨密度变化[J].中国组织工程研究,2016,20(27):3963-3969,7.基金项目
河南科技发展研究项目(A20140301)@@@@the Science and Technology Development Research Project ofHenan Province, No. A20140301 （A20140301）
