中国组织工程研究2016，Vol.20Issue(27)：3970-3976,7.DOI:10.3969/j.issn.2095-4344.2016.27.003
利塞膦酸钠干预骨质疏松模型大鼠髁突软骨Bcl-2、Bax及Caspase3的表达
Effects of bisphosphonates on the expression of Bcl-2, Bax and Caspase-3 in condylar cartilage of osteoporosis rats
摘要
Abstract
RESULTS AND CONCLUSION:(1)The number of apoptotic cels in rat condylar cartilage and subcondylar region: the sham operation group < the treatment group < the model group (alP< 0.05). (2)Expression of Bcl-2: The trend of the model group was lower than that in the sham operation group, although there was no statisticaly significant difference between the two groups; Bcl-2 expression in the treatment group was statisticaly higher compared to the model group (P< 0.05).(3)Expression of Bax and Caspase-3: The expression levels of Bax and Caspase-3 were higher in the model group than in the sham operation group (alP< 0.05), while Bax and Caspase-3 expression was lower in the treatment group than that in the model group (alP< 0.05). The results suggested that bisphophonates can regulate apoptosis in condylar cartilage from osteoporosis rats by changing the expression of Bcl-2, Bax and Caspase-3.关键词
实验动物/骨软骨损伤与修复动物模型/二膦酸盐/骨质疏松/去卵巢/下颌骨髁突软骨/TUNEL/Bcl-2/Bax/Caspase3分类
医药卫生引用本文复制引用
周琦,魏立,江莉婷,李宁,高益鸣..利塞膦酸钠干预骨质疏松模型大鼠髁突软骨Bcl-2、Bax及Caspase3的表达[J].中国组织工程研究,2016,20(27):3970-3976,7.基金项目
上海高校教师产学研践习计划@@@@the Plan Learning and Research Practice of University Teachers in ShanghaiCity （）
