中国医疗设备2016，Vol.31Issue(6)：13-18,35,7.DOI:10.3969/j.issn.1674-1633.2016.06.003
基于病人自体肿瘤细胞体外培养模型的个体化精准用药
Precise Medicine in Cancer Treatmentvia Patient Derivedin Vitro Tumor Model
摘要
Abstract
The concept of precise medicine opens a new gate for cancer treatment. Nowadays, gene mutations possibly responsible for chemotherapeutic sensitivity can be pinpointed based on the Whole Genome Sequencing (WGS) technology to attack the tumor targeting to specific mutation. However, gene sequencing probably is not capable of providing the most suitable drug usage solution due to tumor genetic instability. In addition to the WGS, precise medicine also includes drug sensitivity testing. Chemo-sensitivity drug testing with patient derived primary tumorin vitro model can provide more direct and accurate medical indication compared with the WGS because critical information for drug usage, such as pharmacological analysis and drug efficiency, can be acquired simply. The combination of genetic analysis and in vitro model screening is helpful to ifnd the most promising drug or drug combination for each patient and thus achieves the personalized medicine and increases tumor treatment efifciency. This paper discussed the history, status, perspectives of current method of patient derived tumorin vitro model.关键词
精准医疗/病人自体肿瘤细胞/药敏检测/三维培养Key words
precise medicine/patient derived tumor cells/drug sensitivity testing/3D cell culture分类
医药卫生引用本文复制引用
朱路,勾越阳,鄢晓君,周律,廖泉,王斌,叶春祥,冯长江,杜亚楠..基于病人自体肿瘤细胞体外培养模型的个体化精准用药[J].中国医疗设备,2016,31(6):13-18,35,7.基金项目
国家自然科学基金（81171474、51273106、51461165302），北京市自然科学基金（157142090）。 （）
