中国医疗设备2016，Vol.31Issue(6)：19-23,35,6.DOI:10.3969/j.issn.1674-1633.2016.06.004
个体化精准抗癌光动力疗法综述
Overview of Personalized Precise Photodynamic Therapy
摘要
Abstract
The conventional techniques for cancer treatment include chemotherapy, radiotherapy, and surgery. However, chemotherapy often brings systemic side-effects, radiation therapy is limited by the cumulative radiation dose, and surgical resection of tumors is not suitable for repeated therapy. Photodynamic therapy (PDT) is an emerging precise intervention for cancer treatment, but it is yet limited to superficial lesions because of low penetration of visible light. Recently, upconversion technology was proposed as a transferring agent for PDT. It is excited by near infrared (NIR) and able to emit visible light. Without toxicity, NIR is good at tissue penetration. Therefore, upconversional PDT (UPDT) is very useful for treating solid and large tumors. One of the remaining issues is that most cancerous lesions lie inside human body and beneath deep tissues. In other words, they are still out of NIR penetration. The development of micro/nano circuits and systems for wireless power implants is studied in this paper, which are possibly employed for long-term PDT of deeply situated tumors. Furthermore, it is possible to remote control these implants that are directly placed nearby cancerous lesions. Once integrated with UPDT, such wireless power implants are capable of treating deeply situated large tumors. In conclusion, this new technology is promising to advance UPDT for precise tumor treatment.关键词
精准治疗/光动力疗法/上转换/植入体/无线传能技术Key words
precise treatment/photodynamic therapy/upconversion/implant/wireless powering分类
医药卫生引用本文复制引用
胡继辉,王倩倩,张勇,李炳南..个体化精准抗癌光动力疗法综述[J].中国医疗设备,2016,31(6):19-23,35,6.基金项目
国家自然科学基金（61271123、31328009、61571176、61511140099），安徽省杰出青年科学基金（1608085J04），安徽省国际科技合作计划（1503062015）。 （）
