中国感染控制杂志2016，Vol.15Issue(6)：374-379,6.DOI:10.3969/j.issn.1671-9638.2016.06.003
2012-2015年某三甲医院血培养常见病原菌及其耐药性变迁
Distribution and changes in antimicrobial resistance of pathogens from blood culture in a tertiary first-class hospital in 2012-2015
摘要
Abstract
Objective To investigate the distribution and change in antimicrobial resistance of pathogens causing blood-stream infection,so as to provide reference for rational antimicrobial use.Methods The isolation and antimicrobial resistance of major pathogens from blood culture specimens from a tertiary first-class hospital in 2012-2015 were analyzed statistically.Results A total of 4 780 isolates were detected,the top five species were Escherichia coli (n = 1 008, 21.09%),Klebsiella pneumoniae (n = 624,13.05%),Acinetobacter baumannii (n = 452,9.46%),Staphylococcus aureus (n=437,9.14%),and Pseudomonas aeruginosa (n=247,5.17%).The percentage of gram-negative bacilli, gram-positive cocci,fungi,and others were 62.05%,29.31%,7.76%,and 0.88% respectively.The resistance rates of Klebsiella pneumoniae to ertapenem and imipenem increased from 4.50% in 2012 to 46.79% and 33.94% in 2015(both P<0.01).The resistance rates of Acinetobacter baumannii to cefepime,ceftazidime,tobramycin,gentamicin,and imipenem were 86.50%,80.56%,78.10%,79.87%,and 84.29% respectively;resistance rates to amikacin in 2012-2015 were 0, 10.22%,39.85%,and 21.30% respectively(P<0.01);resistance rates to minocycline in four years were 0-7.52% (P<0.01 ).Conclusion The main pathogens causing bloodstream infection are gram-negative bacilli,Acinetobacter baumannii is highly resistant to cephalosporins and carbapenems,resistance rates of Klebsiella pneumoniae to carbapenems increased rapidly.Broad-spectrum antimicrobial agents must be used cautiously to reduce the selective pressure of antimicrobial agents.关键词
血流感染/血培养/病原菌/耐药性/抗药性,微生物/合理用药Key words
bloodstream infection/blood culture/pathogen/drug resistance/drug resistance,microbial/rational antimicrobial use分类
医药卫生引用本文复制引用
刘乐平,刘文恩,晏群,刘清霞,邹明祥,李艳明,李虹玲..2012-2015年某三甲医院血培养常见病原菌及其耐药性变迁[J].中国感染控制杂志,2016,15(6):374-379,6.基金项目
湖南省教育厅课题资助 （）
