中国感染控制杂志2016，Vol.15Issue(6)：384-387,392,5.DOI:10.3969/j.issn.1671-9638.2016.06.005
替加环素联合头孢哌酮／舒巴坦治疗耐药鲍曼不动杆菌颅内感染临床研究
Clinical study of tigecycline combined with cefoperazone/sulbactam for treatment of intracranial infection with drug-resistant Acinetobacter bau-mannii
陈红伟 1娄元华 1李小勇 1潘栋超 1解东成 1刘东升1
作者信息
- 1. 中国医科大学航空总医院，北京 100012
- 折叠
摘要
Abstract
Objective To evaluate clinic efficacy and safety of tigecycline combined with cefoperazone/sulbactam for treatment of intracranial infection with drug-resistant Acinetobacter baumannii (DRAB).Methods 12 patients with DRAB intracranial infection admitted in a department of neurosurgery between January 2014 and April 2015 were analyzed retrospectively,clinic efficacy and safety of tigecycline combined with cefoperazone/sulbactam for treatment of DRAB intracranial infection were evaluated.Results After patients received tigecycline combined with cefoperazone/sulbactam for 12-62 days (39.5 days on average), clinical symptoms and signs (including body temperature,signs of meningeal irritation)of most patients were significantly improved compared with before treat-ment,3 cases were cured,5 were markedly effective,4 abandoned or ineffective(death).The overall effective rate was 66.67%(8/12),mortality was 33.33% (4/12);bacterial clearance rate of cerebrospinal fluid (CSF)was 83.33%(10/12).Causes of death:2 were with failure of brain stem following craniocerebral trauma,1was extensive parenchymal infection,1was recurrence of intracranial infection and formation of brain abscess after withdrawing an-timicrobial agents.No significant adverse reaction occurred during the treatment period.Conclusion On the basis of keeping CSF drainage unobstructed,long course treatment of tigecycline combined with cefoperazone/sulbactam can effectively eliminate DRAB from CSF,and has a good safety.关键词
替加环素/鲍曼不动杆菌/头孢哌酮/舒巴坦/颅内感染/脑脊液Key words
tigecycline/Acinetobacter baumannii/cefoperazone/sulbactam/intracranial infection/cerebrospinal fluid分类
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陈红伟,娄元华,李小勇,潘栋超,解东成,刘东升..替加环素联合头孢哌酮／舒巴坦治疗耐药鲍曼不动杆菌颅内感染临床研究[J].中国感染控制杂志,2016,15(6):384-387,392,5.
