中国全科医学2016，Vol.19Issue(16)：1882-1886,5.DOI:10.3969/j.issn.1007-9572.2016.16.007
中老年代谢综合征患者合并冠心病对肾功能的影响研究
Influence of Metabolic Syndrome Complicated With Coronary Heart Disease on Renal Function on the Middle-aged and ;Elderly Patients
摘要
Abstract
Objective To explore the influence of metabolic syndrome( MS)complicated with coronary heart disease (CHD)on renal function on the middle-aged and elderly patients. Methods From July to December 2014,we selected 3 676 in-service and retired employees who had received physical examination test related to " type 2 diabetes prevention study on Huai'an City" in Huai'an Second People's Hospital. 1 988 cases of diagnosed with MS in the case group and 1 688 cases of no CHD and MS in the control group. The case group were divided into MS group ( n=1 811 )and MS+CHD group ( n=177 ) according to whether complicated with CHD. We collected and compared the three groups of participants ’ general information. Using multiple linear regression analysis to investigate the influencing factors of estimated glomrular filtration rate ( eGFR)in MS patients and using multivariate Logistic regression analysis to investigate the influencing factors of MS patients complicated with chronic renal diseases(CKD). Results Three groups were significantly different in gender,average age, smoking,drinking, BMI, waist circumference ( WC ), systolic blood pressure ( SBP ), diastolic blood pressure ( DBP ), fasting plasma glucose(FPG),glycosylated hemoglobin(HbA1c),total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C)and ALT(P﹤0. 05)and were not significantly different in AST(P﹥0. 05). Three groups were significantly different in proportion of combined with CKD,serum creatinine (SCr),blood urea nitrogen(BUN),eGFR(P ﹤ 0.05).Multiple linear regression analysis showed that gender,age, drinking,SBP,FPG,HbA1c,TG,LDL-C and ALT complicated CHD were significantly different in influencing of eGFR in MS patients(P﹤0. 05). After correcting confounding factors,gender,age,drinking,FPG,TG,LDL-C and complicated with CHD were significantly different in influencing of eGFR ( P﹤0. 05 ) . Complicated with CHD can lead to MS patients in eGFR decreased by roughly 4. 094 ml·min-1·(1. 73 m2)-1. Multivariate Logistic regression analysis showed that gender,age,TC, LDL-C and complicated with CHD were significantly different in MS patients complicated with CKD(P﹤0. 05). After correcting confounding factors, gender, age, TC, LDL-C and complicated with CHD were significantly different in MS patients complicated with CKD(P﹤0. 05). The risk of CKD in MS patients complicated with CHD was 2. 043 times that in simple MS patients. Conclusion CHD can aggravate the damage of renal function in MS patients. The clinical value should be paid attention to the renal function evaluation of MS patients complicated with CHD.关键词
代谢综合征X/冠心病/肾功能/中老年Key words
Metabolic syndrome X/Coronary disease/Renal function/Middle-aged and aged分类
医药卫生引用本文复制引用
郝海荣,张勇,程亮,徐晓文,胡文,俞伟男,周红文..中老年代谢综合征患者合并冠心病对肾功能的影响研究[J].中国全科医学,2016,19(16):1882-1886,5.基金项目
江苏省卫生厅基金项目 （）
